Heart disease remains the leading cause of death among women in the United States, yet many women remain unaware of their cardiovascular risk. There are sex and gender differences in terms of risk and symptoms for heart disease. Here is more information on women’s heart health and the role of heart screenings for women over 40:
Understanding Cardiovascular Risk Changes
Women’s heart health changes significantly as they age, particularly around menopause. Estrogen levels decline during this period, which affects how the body processes cholesterol and maintains blood vessel health. Research shows that women’s risk of heart disease increases substantially after age 40, with the risk doubling approximately every decade.

Blood pressure tends to rise with age, and cholesterol levels often shift unfavorably. Weight gain becomes more common, and insulin resistance may develop. Family history of heart disease also becomes more relevant as women reach this age group, as genetic predispositions often manifest during middle age.
Women over 40 also face unique risk factors that differ from those affecting men. Conditions such as gestational diabetes, preeclampsia during pregnancy, and polycystic ovary syndrome can increase cardiovascular risk later in life. Women may experience heart disease symptoms differently from men, making early detection through screening more valuable.
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Exploring Screenings and Applications
Heart screenings for women over 40 typically include several different assessments. Blood pressure measurement forms the foundation of cardiovascular screening, as hypertension often develops without symptoms. Healthcare providers recommend checking blood pressure at least every two years for women with normal readings. It might be performed more frequently for those with elevated levels.
Cholesterol testing provides another key component of heart screening. This blood test measures total cholesterol, LDL (low-density lipoprotein), HDL (high-density lipoprotein), and triglycerides. Women should have cholesterol checked every four to six years starting at age 20, with more frequent testing after 40 or if risk factors are present.
Additional screenings may include electrocardiograms (ECGs) to assess heart rhythm and detect abnormalities. Blood glucose testing is used to identify diabetes risk. Some women may benefit from more advanced screenings such as stress tests or coronary calcium scoring, particularly if they have multiple risk factors or a strong family history. Body mass index (BMI) calculation and waist circumference measurement also form part of comprehensive cardiovascular risk assessment.Â
Making Informed DecisionsÂ
Women over 40 should discuss their cardiovascular risk profile with their healthcare provider to determine the most appropriate screening schedule. This conversation should include personal medical history, family history, lifestyle factors, and any symptoms that may suggest cardiovascular problems. The discussion should cover risk factors such as smoking, physical activity levels, dietary habits, and stress management.Â
Stress management techniques may also play a role in cardiovascular health maintenance. Women should also understand that cardiovascular symptoms in women may differ from the classic chest pain often associated with heart problems in men. Symptoms such as shortness of breath, fatigue, nausea, or pain in the arms, back, or jaw may indicate heart problems and warrant immediate medical attention.
Learn About Women’s Heart Health
Heart screenings provide valuable information about cardiovascular risk, but they represent just one component of heart health management. Regular screening allows for early detection of risk factors such as high blood pressure, abnormal cholesterol levels, and diabetes, which can be addressed before they lead to more serious complications. Women over 40 should work with their healthcare providers to establish a screening schedule that matches their individual risk profile.Â